Hasan Khatib

Hasan Khatib

Professor-Animal Science

632 Animal Science Building

1675 Observatory Drive

Khatib Lab

Phone: 608-263-3484

Email: hkhatib@wisc.edu

Research Description

Infertility has become a challenge in many mammalian species. In humans, about 15% of couples fail to conceive within the course of a year of unprotected sex. Within the United States, 11.0 % of women ages 15-44 have impaired fecundity and about 6% are infertile. Assisted reproductive technologies have become well developed and utilized to overcome some of the challenges of infertility. However, assessment of embryo quality and potential of in vivo and in-vitro produced embryos is largely based on morphology which is often not indicative of the embryo's ability to establish a pregnancy. Thus, the objectives of my research are to identify and characterize genes and epigenetic markers as predictors of embryo development using non-invasive methods. We are investigating the roles of imprinted genes and epigenetic modifications in early embryonic development. Another focus of my research is the investigation of the effects of maternal nutrition on the transcriptome and epigenome of the offspring. Methods used in our lab include genome-wide association studies, RNA-Seq, DNA methylation, CRISPR, microRNAs, and RNAi.

Affiliations

Animal Sciences

Training Programs

ERP

Selected Publications

  • Driver A, Huang W, Kropp J, Peñagaricano F, and Khatib H (2013) Knockdown of CDKN1C (p57kip2) and PHLDA2 results in abnormal development of bovine pre-implantation embryos. PLoS One 8(7): e69490.
  • Lan X, Cretney EC, Kropp J, Khateeb K, Berg MA, Peñagaricano F, Magness R, Radunz AE, and Khatib H (2013) Maternal diet during pregnancy induces transcriptomic and epigenomic changes in fetal tissues in sheep. Front. Gene. 4:49.